New Lipid Nanoparticle Formulation System Labmate Online

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Knauer, the supplier of Lipid Nanoparticle (LNP) production units, used by major pharmaceutical companies for their production of mRNA-based Corona vaccines, now offers a benchtop system, designed for research and development as well as for preclinical and small-scale studies. production of lipid nanoparticles.

The IJM NanoScaler system is designed for lipid nanoparticle R&D – enabling scientists to determine the optimal process parameters for the formulation of lipid nanoparticles containing APIs. These active pharmaceutical ingredients include complex or delicate APIs like RNA, mRNA, siRNA, and DNA-based molecules, or products that require specific entry into target cells.

Equipped with Knauer’s Impingement Jets Mixing (IJM) technology for producing lipid nanoparticles, the NanoScaler allows researchers to optimize encapsulation conditions for their nucleotide therapy before scaling up the process to work on a larger GMP-compliant IJM NanoProducer unit.

The IJM NanoScaler is designed for low sample consumption so that valuable APIs are not wasted. Its small footprint allows it to sit comfortably on the bench of a research and development laboratory.

The system comes with five different Knauer Impingement Jets mixers to help researchers determine which conditions result in the optimal level of API encapsulation. Additionally, researchers can use their own custom mixing unit and benefit from the flexibility of system configuration.

The formulation process can be controlled remotely by software; run from a conventional PC or laptop, or even a tablet.

The NanoScaler IJM allows the screening of several key parameters during the encapsulation step of the lipid nanoparticles: geometries of the mixing units; flow rates and mixing ratios; various formulations of lipids; dilution protocols.

The IJM NanoScaler can be used to produce lipid-encapsulated API in the range of 1ml to hundreds of milliliters, meaning the system is perfect for proof-of-concept testing and optimization of process, preclinical testing, e.g. for in vitro studies, as well as small-scale production.

More information online

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